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Curriculum Vitae


Betty J. Gaffney


October 26, 2012


General Information


University address: Biological Science
College of Arts and Sciences
Biology Unit I 0113
Florida State University
Tallahassee, Florida 32306-4370
Phone: 850-644-8547; Fax: 850-644-0481

E-mail address: gaffney@bio.fsu.edu


Web site: http://www.bio.fsu.edu/faculty-gaffney.php


Professional Preparation


1966 Ph.D., Stanford University. Major: Chemistry.


1961 B.S., Stanford University. Major: Chemistry.


Postdegree Education and Training


1967–1968 Varian Associates Postdoctoral Fellow, Chemistry, Tohoku University, Sendai, Japan.


1966–1967 NIH Postdoctoral Research Associate, Chemistry, Tohoku University, Sendai, Japan.


Professional Experience


1996–present Professor, Biological Science, Florida State University.


1989–1996 Adjunct Professor, Biophysics, Johns Hopkins University, Baltimore, Maryland.


1985–1996 Adjunct Professor, Biology, Johns Hopkins University, Baltimore, Maryland.


1982–1996 Professor, Chemistry, Johns Hopkins University, Baltimore, Maryland.


1994–1995 Acting Co-Director, Institute for Biophysical Research on Macromolecular Assemblies, Johns Hopkins University, Baltimore, Maryland.


1977–1982 Associate Professor, Chemistry, Johns Hopkins University, Baltimore, Maryland.


1974–1977 Assistant Professor, Chemistry, Johns Hopkins University, Baltimore, Maryland.


1969–1973 Research Associate, Chemistry, Stanford University, Stanford, California.


Visiting Professorship(s)


1996 Visiting Professor at Weizmann Institute, Rehovot, Israel (2 weeks).


1973 Visiting Research Associate, Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts (periods of several months).


Fellowship(s)


Fellow of The Biophysical Society (2009).


Honors, Awards, and Prizes


Fellow, The Biophysical Society (2009).


Current Membership in Professional Organizations


American Society for Advancement of Science

American Society for Biochemistry and Molecular Biology

Biophysical Society

Federation of American Societies of Experimental Biology (FASEB)

International EPR Society

International Society for Magnetic Resonance


Teaching


Courses Taught


Experimental Biology Laboratory (BSC3402L)

Selected Topics in Biological Science: Enzyme Reaction Intermediates (BSC5936)

Selected Topics in Biological Science: Physical Biology of Cell (BSC4933)

Graduate Tutorial in Biological Science (BSC5932)

Selected Topics in Biological Science: Proteins (BSC4933)

Selected Topics in Biological Science: Molecular Disease (BSC4933)

Selected Topics in Biological Science: Advances in Biophysics (BSC4933)

Senior Tutorial in Biological Science (BSC4931)

Cell Structure and Function (PCB3134)

Seminar in Botany (BOT6936)

Selected Topics in Biological Science: Reactive Oxygen Species (BSC4933)

Introductory Biology Lab (BSC2010L)

Selected Topics in Biological Science: Electron Transfer (BSC4933)

Methods in Biophysical Chemistry

NMR studies of peptides, EPR studies of diffusion, EPR imaging

Physical Chemistry Instrumentation Lab, for undergraduate students

Introduction to Magnetic Resonance, for graduate students


Doctoral Committee Chair


Wu, F., graduate. (2006). Elucidation of the Catalytic Mechanism of Two Fatty Acid-Metabolizing Enzymes Using EPR Spectroscopy.


Maguire, B., graduate. (1999). Expression of Apolipoprotein C-II: Structural and Biophysical Studies.


Kutbuddin S. Doctor, graduate. (1998). Expression of Apolipoprotein C-II: Structural and Biophysical Studies.


Yang, An-Suei, graduate. (1987). EPR Studies of Phenylalanine Hydroxylase, Transferrin and Spin Labeled Phosphorylaseb.


Mavrophilipos, D., graduate. (1986). Characterization of the Iron Environment of Lipoxygenases.


Willingham, G., graduate. (1982). Synthesis and Characterization of Spin Labeled Crosslinking Reagents and Their Application to the Study of Erythrocyte Proteins.


Chen, Shaw-Chen, graduate. (1977). The Relationship of Molecular Structure to Cooperative Processes in Lipid Bilayers.


Bradshaw, M. D., doctoral student.


Doctoral Committee Cochair


Boyington, J., graduate. (1994). The Crystal Structure of Soybean Lipoxygenase-1 Determined to 2.6 Å Resolution.


Doctoral Committee Member


Caudle, S. B., doctoral student.

Frausto, S. D., doctoral student.


Doctoral Committee University Representative


Porter, C. M., doctoral student.


Master's Committee Chair


Imber, A., graduate. (2004).

Ottenberg, G., graduate. (2004).

Averett, D., graduate. (1996).

Tevelrakh, E., graduate. (1995).

Mihailovic, A., graduate. (1989).

Grumbling, M., graduate. (1986).

Elbrecht, C., graduate. (1979).

Jones, M. B., graduate. (1978).


Supervision of Student Research Not Related to Thesis or Dissertation


Abrahams, C. (2012).


Skamangas, N. (2011–12).


Reinthaler, T. (2010).


Bradshaw, M. (2009–10).


Frausto, S. (2008).


Giovinazzo, H. (2008–09).


Chaplin, A. (2006).


Katz, B. (2006–08).


Austin, J. (2004).


Imber, A. (2003).


Ottenberg, G. (2002).


Katsir, L. (2000–03).


Castner, M. (1999).


Shriner, A. (1999–2000).


Betsey, K. (1998–99).


Chacko, S. (1995–96).


Lang, D. (1992).


VonTiesenhausen, K. (1991–94).


Dagdigian, E. (1989–90).


Edidin, A. (1984).


Mavrophilipos, Z. (1984–87).


Cheung, A. (1981).


Kelly, R. (1980).


Reed, W. (1980).


Grill, H. (1979).


Scibilia, J. (1979).


Doering, E. (1978–79).


Mich, R. (1975).


Polk, M. (1975).


Schepp, R. (1974–76).


Additional Teaching Not Reported Elsewhere


Gaffney, B. J. (1998–1999). Supervision of postdoctoral associate Guenter Maresch. Florida State University.


Gaffney, B. J. (1997–1998). Supervision of postdoctoral associate Tom Morgan. Florida State University.


Gaffney, B. J. (1996). Participant, IPMB training grant. Johns Hopkins University.


Gaffney, B. J. (1996–1997). Supervision of postdoctoral associate Victoria Kofman. Florida State University.


Gaffney, B. J. (1996–1999). Supervision of postdoctoral associate Brendan Maguire. Florida State University.


Gaffney, B. J. (1991–1994). Supervision of postdoctoral associate Antonio Colom. Johns Hopkins University.


Gaffney, B. J. (1986). Supervision of postdoctoral associate Dimitrios V. Mavrophilipos. Johns Hopkins University.


Gaffney, B. J. (1979–1983). Supervision of postdoctoral associate Ronald Scheule. Johns Hopkins University.


Gaffney, B. J. (1978–1979). Supervision of postdoctoral associate Man Wing Tse. Johns Hopkins University.


Gaffney, B. J. (1977–1978). Supervision of postdoctoral associate Shaw-Chen Chen. Johns Hopkins University.


Gaffney, B. J. (1976–1977). Supervision of postdoctoral associate Elizabeth Rowe. Johns Hopkins University.


Gaffney, B. J. (1974–1977). Supervision of postdoctoral associate Diane C. Lin. Johns Hopkins University.


Research and Original Creative Work


Program of Research and/or Focus of Original Creative Work


Biology of unsaturated lipids—primarily enzymes related to this, especially lipoxygenase; magnetic resonance of paramagnetic biomolecules (EPR, metals, spin labels, high-frequency EPR of metalloproteins; chemical biology of eicosanoids.


Publications


Refereed Journal Articles


Garreta, A., Pompeia, S., García-Fernández, Q., Busquets, M., Juan, C., Oliver, A., Ortiz, A., Gaffney, B. J., Fita, I., Manresa, &., & Carpena, X. (submitted). Structure, Interaction with membranes and contribution to invasibility of a secretable lipoxygenase from Pseudomonas aeruginosa. Manuscript submitted for publication.


Gaffney, B. J., Bradshaw, M. D., Frausto, S., Wu, F., Freed, J. H., & Borbat, P. (in press). Online supplement to "Locating a lipid at the portal to the lipoxygenase active site". Biophysical Journal.


Gaffney, B. J., Bradshaw, M. D., Frausto, S., Wu, F., Freed, J. H., & Borbat, P. (in press). Locating a lipid at the portal to the lipoxygenase active site. Biophysical Journal.


Gaffney, B. J. (2007). Anesthesia, analgesia and euphoria. Biophysical Journal, 92, 1–2.


Wu, F., & Gaffney, B. J. (2006). Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1. Biochemistry, 45, 12510–12518.


Youn, B., Sellhorn, G. E., Mirchel, R. J., Gaffney, B. J., Grimes, H. D., & Kang, C.-H. (2006). Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms, LOX-1 and LOX-3. PROTEINS: Structure, Function, and Bioinformatics, 65, 1008–1020.


Coffa, G., Imber, A. N., Maguire, B. C., Laxmikanthan, G., Schneider, C., Gaffney, B. J., & Brash, A. R. (2005). On the relationships of substrate orientation, hydrogen abstraction and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. Journal of Biological Chemistry, 280, 38756–38766.


Agarwalla, S., Stroud, R. M., & Gaffney, B. J. (2004). Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies. Journal of Biological Chemistry, 279, 34123–34129.


Wu, F., Katsir, L. J., Seavy, M., & Gaffney, B. J. (2003). Role of radical formation at Y193 in the allene oxide synthase domain of a lipoxygenase-AOS fusion protein from coral. Biochemistry, 42, 6871–6880.


Abraham, B., Sono, M., Boutaud, O., Shriner, A., DawsonJ. H., Brash, A. R., & Gaffney, B. J. (2001). Characterization of the coral allene oxide synthase active site with magnetic circular dichroism and electron paramagnetic resonance spectroscopy: evidence for tyrosinate-ligation to the ferric enzyme heme iron. Biochemistry, 40, 2251–2259.


Gaffney, B. J., Su, C., & Oliw, E. H. (2001). Assignment of EPR transitions in a manganese-containing lipoxygenase and prediction of local structure. Applied Magnetic Resonance, 21, 411–422.


Bowers, C. R., Storhaug, V., Webster, C. E., Bharatam, J., Cottone, A., III, Gianna, R., Betsey, K., & Gaffney, B. J. (1999). Exploring protein surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR. Journal of the American Chemical Society, 121, 9370–9377.


Gaffney, B. J., Maguire, B. C., Weber, R. T., & Maresch, G. G. (1999). Disorder at metal sites in proteins: a high frequency EMR study. Applied Magnetic Resonance, 16, 207–222.


Grant, C. V., Cope, W., Ball, J. A., Campbell, K., Maresch, G. G., Gaffney, B. J., Fink, W., & Britt, R. D. (1999). Electronic structure of the aqueous vanadyl ion probed by 9 and 94 GHz EPR and pulsed ENDOR spectroscopies and density functional theory calculations. Journal of Physical Chemistry B, 103, 10627–10631.


Gaffney, B. J., Eaton, G. R., & Eaton, S. S. (1998). Electron spin relaxation rates for high-spin Fe(III) in iron transferrin carbonate and iron transferrin oxalate. Journal of Physical Chemistry, 102, 5536–5541.


Gaffney, B. J., & Marsh, D. (1998). High-frequency, spin label EPR of non-axial ordering and motion in cholesterol-containing membranes. Proceedings of the National Academy of Sciences of the USA, 95, 12940–12943. Retrieved from PMID: 9789019


Gaffney, B. J., & Silverstone, H. J. (1998). Simulation methods for looping transitions. Journal of Magnetic Resonance, 134, 57–66.


Prigge, S. T., Gaffney, B. J., & Amzel, L. M. (1998). Relation between positional specificity and chirality in mammalian lipoxygenases. Nature Structural Biology, 5, 178–179.


Boyington, J. C., Gaffney, B. J., & Amzel, L. M. (1997). The three dimensional structure of soybean lipoxygenase-1: an arachidonic acid 15-lipoxygenase. Advances in Experimental Medicine and Biology, 400A, 133–138.


Maguire, B. C., & Gaffney, B. J. (1997). Interdoublet transitions in S=5/2 protein systems. Solid State NMR, 9, 81–83.


Prigge, S. T., Boyington, J. C., Faig, M., Doctor, K. S., Gaffney, B. J., & Amzel, L. M. (1997). Structure and mechanism of lipoxygenases. Biochimie, 79, 629–636.


Doctor, K. S., & Gaffney, B. J. (1996). High frequency EPR predictions for the non-heme iron protein lipoxygenase. Applied Magnetic Resonance, 11, 425–435.


Gaffney, B. J. (1996). Lipoxygenases: structural principles and spectroscopy. Annual Reviews of Biophysics and Biomolecular Structure, 25, 431–59.


Gaffney, B. J. (1996). Origins of biological magnetic resonance. FASEB Journal, 10, 1448–1449.


Prigge, S. T., Boyington, J. C., Gaffney, B. J., & Amzel, L. M. (1996). Structure conservation in lipoxygenases: structural analysis of soybean lipoxygenase-1 and modeling of human lipoxygenases. Proteins: Structure, Function, and Genetics, 24, 275–291.


Amzel, L. M., & Gaffney, B. J. (1995). Structural immunology: problems in molecular recognition. FASEB Journal, 9, 7–8.


Crowder, M. W., Stewart, J. D., Roberts, V. A., Bender, C. J., Tevelrakh, E., Taylor, S. D., Hawkins, P. C. D., Franklin, S., Peisach, J., Getzoff, E. D., Gaffney, B. J., & Benkovic, S. J. (1995). Spectroscopic studies on the designed metal-binding sites of the 43C9 single chain antibody. Journal of the American Chemical Society, 117, 5627–5634.


Boyington, J. C., Gaffney, B. J., Amzel, L. M., Doctor, K. S., Mavrophilipos, D. V., Mavrophilipos, Z. V., Colom, A., & Yuan, S. M. (1994). The X-ray structure and biophysical studies of a 15-lipoxygenase. Annals of the New York Academy of Science, 744, 310–313.


Boyington, J. C., Gaffney, B. J., & Amzel, L. M. (1993). Structure of soybean lipoxygenase-1. Biochemical Society Transactions, 21, 744–748.


Boyington, J. C., Gaffney, B. J., & Amzel, L. M. (1993). The three-dimensional structure of an arachidonic acid 15-lipoxygenase. Science, 260, 1482–1486.


Doctor, K. S., Gaffney, B. J., Alvarez, G., & Silverstone, H. J. (1993). EPR spectroscopy of interdoublet transitions in high-spin iron: applications to transferrin oxalate. Journal of Physical Chemistry, 97, 3028–3033.


Gaffney, B. J., Mavrophilipos, D. V., & Doctor, K. S. (1993). Access of ligands to the ferric center in lipoxygenase-1. Biophysical Journal, 64, 773–783.


Dubach, J., Gaffney, B. J., More, K., Eaton, G. R., & Eaton, S. S. (1991). The effect of the synergistic anion on EPR spectra of iron-transferrin anion complexes is consistent with bidentate binding of the anion. Biophysical Journal, 59, 1091–1100.


Boyington, J. C., Gaffney, B. J., & Amzel, L. M. (1990). Crystallization and preliminary X-ray analysis of soybean lipoxygenase-1, a non-heme iron-containing dioxygenase. Journal of Biological Chemistry, 265, 12771–12773.


Yang, A.-S., & Gaffney, B. J. (1990). EPR detection of kinetic responses to photochemically generated protein cofactors. Journal of Magnetic Resonance, 90, 580–583.


Yang, A.-S., & Gaffney, B. J. (1987). Determination of relative spin concentration in some high-spin ferric proteins using E/D-distribution in electron paramagnetic resonance simulations. Biophysical Journal, 51, 55–67.


Benkovic, S. J., Bloom, L. M., Bollag, G., Dix, T. A., Gaffney, B. J., & Pember, S. (1986). The mechanism of action of phenylalanine hydroxylase. Annals of the New York Academy of Science, 471, 226–232.


Bloom, L. M., Benkovic, S. J., & Gaffney, B. J. (1986). Characterization of phenylalanine hydroxylase. Biochemistry, 25, 4204–4210.


Benkovic, S., Wallick, D., Bloom, L., Gaffney, B. J., Domanico, P., Dix, T., & Pember, S. (1985). On the mechanism of action of phenylalanine hydroxylase. Biochemical Society Transactions, 13, 436–438. Retrieved from PMID: 2991038


Gaffney, B. J. (1985). Chemical and biochemical crosslinking of membrane components. Biochimica et Biophysica Acta Reviews on Biomembranes, 822, 289–317.


Wallick, D. E., Bloom, L. M., Gaffney, B. J., & Benkovic, S. J. (1984). The reductive activation of phenylalanine hydroxylase and its effect on the redox state of the nonheme iron. Biochemistry, 23, 1295–1302.


Gaffney, B. J., Willingham, G. L., & Schepp, R. S. (1983). Synthesis and membrane interactions of spin label bifunctional reagents. Biochemistry, 22, 881–892.


Willingham, G. L., & Gaffney, B. J. (1983). Reactions of spin label crosslinking reagents with red blood cell proteins. Biochemistry, 22, 892–898.


Chen, S.-C., Sturtevant, J. M., Conklin, K., & Gaffney, B. J. (1982). Calorimetric evidence for phase transitions in spin-labeled lipid bilayers. Biochemistry, 21, 5096–5101.


Gaffney, B. J., & Scheule, R. K. (1982). What is a successful reconstitution of a membrane glycoprotein that lacks an enzymatic activity? Biophysical Journal, 37, 81–82.


Grill, H., Weigel, N., Gaffney, B. J., & Roseman, S. (1982). Sugar transport by the bacterial phosphotransferase system: XVII. Radioactive and electron paramagnetic resonance labeling of the Salmonella typhimurium phosphocarrier protein HPr at the amino-terminal methionine. Journal of Biological Chemistry, 257, 14510–14517.


Lazarus, R. A., Wallick, D. E., Dietrich, R. F., Gottschall, D. W., Benkovic, S. J., Gaffney, B. J., & Shiman, R. (1982). The mechanism of phenylalanine hydroxylase. Federation Proceedings, 41, 2605–2607.


Gaffney, B. J., Elbrecht, C. H., & Scibilia, J. P. A. (1981). Enhanced sensitivity to slow motions using 15N-nitroxide spin labels. Journal of Magnetic Resonance, 44, 436–446.


Scheule, R. K., & Gaffney, B. J. (1981). Reconstitution of membranes with fractions of Triton X-100 which are easily removed. Analytical Biochemistry, 117, 61–66.


Tse-Tang, M. W., Gaffney, B. J., & Kelly, R. E. (1981). Synthesis of bifunctional spin label molecules and their orientations in membranes. Heterocycles, 15, 965–974.


Chen, S. C., Sturtevant, J. M., & Gaffney, B. J. (1980). Scanning calorimetric evidence for a third phase transition in phosphatidylcholine bilayers. Proceedings of the National Academy of Sciences of the USA, 77, 5060–5063.


Gaffney, B. J., Drachman, D. B., Lin, D. C., & Tennekoon, G. (1980). Spin-label studies of erythrocytes in myotonic dystrophy: no increase in membrane fluidity. Journal of Neurology, 30, 272–276.


Gaffney, B. J. (1979). Spin label-thiourea adducts: a model for saturation transfer EPR studies of slow, anisotropic rotation. Journal of Physical Chemistry, 83, 3345–349.


Sefton, B. M., & Gaffney, B. J. (1979). Complete exchange of viral cholesterol. Biochemistry, 18, 436–442.


Wey, C. L., Cone, R. A., & Gaffney, B. J. (1979). Effects of light and C-GMP on membrane fluidity of frog rod outer segments. Photochemistry and Photobiology, 29, 707–713.


Chen, S. C., & Gaffney, B. J. (1978). Paramagnetic resonance evidence for phase transitions in bilayers of pure spin labeled lipids. Journal of Magnetic Resonance, 29, 341–353.


Gaffney, B. J., & Mich, R. J. (1976). A new measurement of surface charge in model and biological lipid membranes. Journal of the American Chemical Society, 98, 3044–3045.


Gaffney, B. J. (1975). Fatty acid chain flexibility in the membranes of normal and transformed fibroblasts. Proceedings of the National Academy of Sciences of the USA, 72, 664–668.


Gaffney, B. J., & McConnell, H. M. (1974). The paramagnetic resonance spectra of spin labels in phospholipid membranes. Journal of Magnetic Resonance, 16, 1–28.


Gaffney, B. J., & McConnell, H. M. (1974). Effect of a magnetic field on phospholipid membranes. Chemical Physics Letters, 24, 310–313.


Robbins, P. W., Wickus, G. G., Branton, P. E., Gaffney, B. J., Hirschberg, C. B., Fuchs, P., & Blumberg, P. M. (1974). The chick fibroblast cell surface after transformation by Rous sarcoma virus. Cold Spring Harbor Symposium, 39, 1173–1180.


Sefton, B. M., & Gaffney, B. J. (1974). Effect of the viral proteins on fluidity of the membrane lipids in Sindbis virus. Journal of Molecular Biology, 90, 343–358.


Gaffney McFarland, B. (1972). The molecular basis of fluidity in membranes. Chemistry and Physics of Lipids, 8, 303–313.


McConnell, H. M., & Gaffney McFarland, B. (1972). The flexibility gradient in biological membranes. Annals of the New York Academy of Sciences, 195, 207–217.


McConnell, H. M., Wright, K. L., & Gaffney McFarland, B. (1972). The fraction of the lipid in a biological membrane that is in a fluid state: a spin-label assay. Biochemical and Biophysical Research Communications, 47, 273–281.


Gaffney McFarland, B., & McConnell, H. M. (1971). Bent fatty acid chains in lecithin bilayers. Proceedings of the National Academy of Sciences of the USA, 68, 1274–1278.


McConnell, H. M., & Gaffney McFarland, B. (1970). Physics and chemistry and spin labels. Quarterly Reviews of Biophysics, 3, 91–136.


Gaffney McFarland, B., Inoue, Y., & Nakanishi, K. (1969). The reaction of Koshland's protein reagent with tryptophan. Tetrahedron Letters, 10, 857–860.

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