Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.)




НазваниеRecommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.)
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Reference List 5469

C:\web-rbw\5469-2010


NOTE This list is based on last years course and I will be updating as we go through topics.


Temple University has free electronic access to most of these references. Currently my bibliography software does not print out all the links to these articles or the journal sites. Ask the librarian (Thomas Heverin will be covering Biology and Chemistry. 1-4725; thomas.heverin@temple.edu) for some hints on accessing them. I keep a folder on my browser in which I store links to the home or archive pages of journals I use. Some journals require that you log on through a temple computer or at least begin your search through the Temple library homepage so that the IPS address is recognized as coming from a subscriber to the journal.


One or two references are too old to be available on-line.

Required References


Mirkin,S.M. (2007). Expandable DNA repeats and human disease. Nature 447, 932-940.
Abstract: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA. These DNA repeats seem to be predisposed to such expansion because they have unusual structural features, which disrupt the cellular replication, repair and recombination machineries. The presence of expanded DNA repeats alters gene expression in human cells, leading to disease. Surprisingly, many of these debilitating diseases are caused by repeat expansions in the non-coding regions of their resident genes. It is becoming clear that the peculiar structures of repeat-containing transcripts are at the heart of the pathogenesis of these diseases

http://www.nature.com/nature/journal/v447/n7147/full/nature05977.html


If you do no not have access to a textbook which gives an overview of chromatin and chromatin regulation you should read as a foundation for class material:

Felsenfeld,G. and Groudine,M. (2003). Controlling the double helix. Nature 421, 448-453.
Abstract: Chromatin is the complex of DNA and proteins in which the genetic material is packaged inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts profound control over gene expression and other fundamental cellular processes. Changes in its structure can be inherited by the next generation, independent of the DNA sequence itself. http://www.nature.com/nature/journal/v421/n6921/full/nature01411.html

Recommended References. Suggestion: –




Look up the reference on-line. Get the News and Views article too (See end of this ref.)


A lot of structural detail so take note of some of the key procedures, experiments and conclusions .


Luger,K., Mader,A.W., Richmond,R.K., Sargent,D.F., and Richmond,T.J. (1997). Crystal structure of the nucleosome core particle at 2.8 A resolution [see comments]. Nature 389, 251-260.
Abstract: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry.
Notes: http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v389/n6648/full/389251a0_fs.html
News & Views Comments in Nature. 1997 Sep 18;389(6648):251-60 at http://www.nature.com/doifinder/10.1038/38386

Woychik,N.A. and Hampsey,M. (2002). The RNA polymerase II machinery: structure illuminates function. Cell 108, 453-463. A good overview but there are more up to date review articles in the background reference section. Abstract: Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.

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