Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.)




НазваниеRecommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.)
страница4/6
Дата конвертации29.10.2012
Размер94.2 Kb.
ТипДокументы
1   2   3   4   5   6


Need a SNP and GWA paper

DNA polymerases and DNA repair


McCulloch,S.D. and Kunkel,T.A. (2008). The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res. 18, 148-161.
Good overview on selected topics (gets very detailed at points) and does not cover BER or NER.
Abstract: In their seminal publication describing the structure of the DNA double helix, Watson and Crick wrote what may be one of the greatest understatements in the scientific literature, namely that "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material." Half a century later, we more fully appreciate what a huge challenge it is to replicate six billion nucleotides with the accuracy needed to stably maintain the human genome over many generations. This challenge is perhaps greater than was realized 50 years ago, because subsequent studies have revealed that the genome can be destabilized not only by environmental stresses that generate a large number and variety of potentially cytotoxic and mutagenic lesions in DNA but also by various sequence motifs of normal DNA that present challenges to replication. Towards a better understanding of the many determinants of genome stability, this chapter reviews the fidelity with which undamaged and damaged DNA is copied, with a focus on the eukaryotic B- and Y-family DNA polymerases, and considers how this fidelity is achieved.

http://www.nature.com/cr/journal/v18/n1/full/cr20084a.html


Alberts,B. (2003). DNA replication and recombination. Nature 421, 431-435.
Abstract: Knowledge of the structure of DNA enabled scientists to undertake the difficult task of deciphering the detailed molecular mechanisms of two dynamic processes that are central to life: the copying of the genetic information by DNA replication, and its reassortment and repair by DNA recombination. Despite dramatic advances towards this goal over the past five decades, many challenges remain for the next generation of molecular biologists.
Notes: Rather historical review but the end has some new concepts. http://www.nature.com/nature/journal/v421/n6921/full/nature01407.html

Friedberg,E.C. (2003). DNA damage and repair. Nature 421, 436-440.
Abstract: The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution. http://www.nature.com/nature/journal/v421/n6921/full/nature01408.html

Trifunovic,A., Wredenberg,A., Falkenberg,M., Spelbrink,J.N., Rovio,A.T., Bruder,C.E., Bohlooly,Y., Gidlof,S., Oldfors,A., Wibom,R., Tornell,J., Jacobs,H.T., and Larsson,N.G. (2004). Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423.
Abstract: Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in a variety of tissues during ageing in humans, monkeys and rodents. These mutations are unevenly distributed and can accumulate clonally in certain cells, causing a mosaic pattern of respiratory chain deficiency in tissues such as heart, skeletal muscle and brain. In terms of the ageing process, their possible causative effects have been intensely debated because of their low abundance and purely correlative connection with ageing. We have now addressed this question experimentally by creating homozygous knock-in mice that express a proof-reading-deficient version of PolgA, the nucleus-encoded catalytic subunit of mtDNA polymerase. Here we show that the knock-in mice develop an mtDNA mutator phenotype with a threefold to fivefold increase in the levels of point mutations, as well as increased amounts of deleted mtDNA. This increase in somatic mtDNA mutations is associated with reduced lifespan and premature onset of ageing-related phenotypes such as weight loss, reduced subcutaneous fat, alopecia (hair loss), kyphosis (curvature of the spine), osteoporosis, anaemia, reduced fertility and heart enlargement. Our results thus provide a causative link between mtDNA mutations and ageing phenotypes in mammals
http://www.nature.com/nature/journal/v429/n6990/abs/nature02517.html;jsessionid=1E9E3336CEDEE0A42F4CA1E6A4EE8E34
http://www.nature.com/nature/journal/v429/n6990/pdf/nature02517.pdf
Comment in: Nature. 2004 May 27;429(6990):357-9

1   2   3   4   5   6

Похожие:

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconPlease answer and provide any reference citations. This is due Saturday Midnight Eastern Standard Time. Reference Modules/Commentary provided at the end after

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconThis file contains the tables, followed by the appendices, followed by the references. Figures are in a separate file. Due to the way Microsoft Word Works, the endnotes to the appendices are at the end of the references

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconThe views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the United States Air Force

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconDepartment of Electrical and Computer Engineering Recommended Text/Reference Book

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) icon06152012 news am – With Shorashim Insights at end!

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) icon05182012 news am – With Shorashim Insights at the end

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) icon03092012 news am – With Shorashim Insights at the end

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconTerms of Reference: Article on ‘ Local governance and sustainability ’

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconOff-Line/Stand-By/back-up ups; Line-Interactive; On-Line. Источники бесперебойного питания типа Off-Line
Источники бесперебойного питания, согласно действующим стандартам, классифицируют по принципу действия на три основные группы

Recommended References. Suggestion: – Look up the reference on-line. Get the News and Views article too (See end of this ref.) iconPublication Date Encyclopedia Article Title Reference Book Title


Разместите кнопку на своём сайте:
lib.convdocs.org


База данных защищена авторским правом ©lib.convdocs.org 2012
обратиться к администрации
lib.convdocs.org
Главная страница